• Vitiligo Diet and Remedies: A Better Way to Deal the Condition

    In your journey to manage vitiligo, embrace a holistic approach, and explore the potential benefits of a balanced Vitiligo Diet and Remedies, aloe vera, herbal treatments, and natural remedies.

    https://naturalherbsclinic.hpage.com/vitiligo-diet-and-remedies-a-better-way-to-deal-the-condition.html

    #Vitiligo
    #DietandRemedies
    #NaturalHerbsClinic
    Vitiligo Diet and Remedies: A Better Way to Deal the Condition In your journey to manage vitiligo, embrace a holistic approach, and explore the potential benefits of a balanced Vitiligo Diet and Remedies, aloe vera, herbal treatments, and natural remedies. https://naturalherbsclinic.hpage.com/vitiligo-diet-and-remedies-a-better-way-to-deal-the-condition.html #Vitiligo #DietandRemedies #NaturalHerbsClinic
    0 Comments 0 Shares 1850 Views 0
  • This comes pretty close to matching what I see among so-called Christians, although I think it is probably worse than depicted.
    https://notthebee.com/article/new-state-of-theology-study-from-ligonier-and-lifeway-exposes-that-biblical-and-theological-literacy-among-evangelicals-is-at-a-shocking-low
    This comes pretty close to matching what I see among so-called Christians, although I think it is probably worse than depicted. https://notthebee.com/article/new-state-of-theology-study-from-ligonier-and-lifeway-exposes-that-biblical-and-theological-literacy-among-evangelicals-is-at-a-shocking-low
    NOTTHEBEE.COM
    Report: Ligonier and LifeWay say biblical literacy among evangelicals is at a shocking low
    Every two years, Ligonier and Lifeway do a "State of Theology" study to show whether or not evangelicals still hold to biblical beliefs.
    0 Comments 0 Shares 624 Views

  • 10 Herbal Remedies for Common Skin Problems


    Many people may develop skin diseases that affect the skin, Herbal Products for Skin Diseases including Polycythemia Vera, Vitiligo, Tinea Versicolor.
    https://www.natural-health-news.com/10-herbal-remedies-for-common-skin-problems/
    10 Herbal Remedies for Common Skin Problems Many people may develop skin diseases that affect the skin, Herbal Products for Skin Diseases including Polycythemia Vera, Vitiligo, Tinea Versicolor. https://www.natural-health-news.com/10-herbal-remedies-for-common-skin-problems/
    WWW.NATURAL-HEALTH-NEWS.COM
    10 Herbal Remedies for Common Skin Problems
    Skin diseases are numerous and a frequently occurring health problem affecting all ages from the neonates to the elderly and cause harm in number of ways. Maintaining healthy skin is important for a healthy body. Many people may develop skin diseases that affect the skin, Herbal Products for Skin Diseases including Polycythemia Vera, Vitiligo, Tinea […]
    0 Comments 0 Shares 338 Views
  • Global Hydraulic Cylinder Marke industry, market trends, size,growth ,Revenue and outlook 2027.
    The research report provides deep insights into the global market revenue, parent market trends, macro-economic indicators, and governing factors, along with market attractiveness per market segment. The report provides an overview of the growth rate of Hydraulic Cylinder Market during the forecast period. Most importantly, the report further identifies the qualitative impact of various market factors on market segments and geographies. The research segments the Hydraulic Cylinder Market on the basis of product type, application, technology, and region. To offer more clarity regarding the Hydraulic Cylinder Market Industry, the report takes a closer look at the current status of various factors including but not limited to supply chain management, niche markets, distribution channel, trade, supply, and demand and production capability across different countries.

    Hydraulic Cylinder Market Overview:

    This study looks at the market growth drivers and roadblocks for the manufacturer, as well as an assessment of the market's firm strategies, procedures, and financially sound and grow plan. Individual customer requirements can be satisfied through customization and a deep understanding of market opportunities. TheHydraulic Cylinder Market provides a comprehensive overview of the market's competitive landscape and key players. This report can assist with structural planning in light of current industry conditions.

    Expected Growth Value Of Hydraulic Cylinder Market :

    Hydraulic Cylinder Market size was valued at US$ 13.40 Bn. in 2020 and the total revenue is expected to grow at a CAGR of 3.5% through 2021 to 2027, reaching nearly US$ 17.05 Bn.

    Hydraulic Cylinder Market

    Market Scope:

    As per the forecast period 2021-2027, the Hydraulic Cylinder market is expected to grow at a steady rate of between 2021 and 2027. This study covers the Hydraulic Cylinder market and provides a value-based analysis and estimate. This study and analysis of market drivers, restraints, and opportunities affecting the growth of the Hydraulic Cylinder Market is included in this report. The global market has been segmented into four categories: type, source, end-user, and geography (country-wise). The scope of the research is a strategic analysis of the Hydraulic Cylinder market in terms of individual growth trends, future prospects, and the contributions of important sub-market stakeholders. Hydraulic Cylinder market analyses and forecasts for five key regions: North America, Europe, Asia Pacific, the Middle East and Africa (MEA), and Latin America, as well as country-by-country segmentation. Major industry participants' profiles, as well as their strategic orientations, market positioning, and core competence analysis, are offered. The top players in the Hydraulic Cylinder Market are also profiled, with details on their recent competitive advancements, investments, strategic growth, and competitive landscape.

    Get Sample Copy (Including FULL TOC, Graphs and Tables) Of This Report :https://www.maximizemarketresearch.com/request-sample/3211

    Precision Farming Market Drivers:
    The construction industry's difficult and massive infrastructure development projects are growing increasingly complex. Despite the fact that the COVID-19 pandemic has had a negative impact on the construction industry, it is expected to grow significantly following the pandemic, due to improved infrastructure spending in APAC and rebounding European infrastructure investment. Backhoes, excavators, trenchers, road construction planers, and dumpers are among the construction equipment (fitted with hydraulic cylinders) that are projected to see increased demand as a result of new infrastructure development plans and projects. As a result, the market for hydraulic cylinders is expected to grow.

    Hydraulic cylinders use hydraulic fluids, primarily oil, to work. Oil leakage in hydraulic cylinders is caused by a wide variety of reasons including improper fittings and connections, as well as external conditions such as vibrations, shocks, and temperature fluctuations. The problem of leakage exists mostly in industries such as mining and construction, which involve substantial earthworks and the deployment of huge fixed and mobile units in environmentally sensitive locations. This leak is not only costly, but it is also dangerous to the environment and employees. Furthermore, unforeseen leakage causes delays in the aircraft sector, resulting in exorbitant costs, especially when these incidents occur on a regular basis.

    Precision Farming Market Segmentation:
    Based on the Bore Size, the market is segmented into <50 mm, 50–150 mm, and >150 mm. 50–150 mm bore size segment is expected to grow rapidly at a CAGR of xx% during the forecast period 2021-2027. This is due to the rapid development of storage and material handling infrastructure, as well as the upgrading of agricultural equipment and the growth of building activities.

    Based on the Industry, the market is segmented into Agriculture, Construction, Material Handling, Mining, Aerospace and Defense, Automotive, Oil and Gas, and Marine. Agriculture segment is expected to grow rapidly at a CAGR of xx% during the forecast period 2021-2027. Agriculture-based countries in APAC, such as India, Nepal, and Myanmar, are seeing increased demand for agricultural equipment as they ramp up production of wheat, rice, cotton, and sugarcane to meet export demands from the United States, Hong Kong, Germany, and Vietnam, among others. This has resulted in higher expenditures in precision agriculture tools and equipment, which is expected to fuel demand for hydraulic cylinders in the agriculture industry.

    Some prominent players in the Hydraulic Cylinder Market:

    • KYB Corporation
    • Parker-Hannifin Corporation
    • SMC Corporation
    • Jiangsu Hengli Hydraulic
    • Wipro Enterprises
    • HYDAC
    • Burnside Autocyl
    • JARP Industries
    • Kappa Engineering
    • Ligon Hydraulic Cylinder Group
    • Marrel

    Click Here For Instant Inquiry :https://www.maximizemarketresearch.com/inquiry-before-buying/3211

    Regional Insights on Hydraulic Cylinder Market :

    The several sections on regional segmentation provide information on the regional characteristics of the Hydraulic Cylinder Market. This chapter discusses the regulatory environment that will have an impact on the market. It highlights the market’s political landscape & anticipates its impact on the worldwide Hydraulic Cylinder Market industry. Global brands’ presence and availability, as well as the problems they face from fierce competition from local & domestic brands, the influence of domestic tariffs, and trade channels, are all considered. The Hydraulic Cylinder Market report examines the five areas & their distribution by country:

    North America – (U.S., Canada, and Mexico)

    Europe – (U.K., Germany, France, Spain, Italy, Sweden, CIS Countries, and Rest of Europe)

    Asia Pacific – (China, India, Japan, South Korea, Australia, ASEAN, and Rest of APAC)

    Middle East & Africa – (South Africa, GCC Countries, Nigeria, Egypt, and Rest of ME&A)

    South America – (Brazil, Argentina, Colombia, and Rest of South America)

    COVID-19 Impact Analysis on Hydraulic Cylinder Market:

    The recovery phase of the COVID-19 outbreak has come to an end over the world. Maximize Industry Research has released the Hydraulic Cylinder Market Status, Trends, and COVID-19 Impact Report 2021, which gives a detailed look at the Hydraulic Cylinder market in light of the present economic situation.

    To Gain More Insights into the Market Analysis, Browse Summary of the Research Report :https://www.maximizemarketresearch.com/market-report/global-hydraulic-cylinder-market/3211/

    The report provides insights on the following:

    Market Penetration: Offers complete information on the market offered by the key players
    Market Development: Provides in-depth information about emerging market trends and analyses the markets
    Competitive Assessment & Intelligence: Provides a comprehensive assessment of market shares, strategies, products, and manufacturing capabilities of the leading key players operating in the market
    Contact us:

    MAXIMIZE MARKET RESEARCH PVT. LTD.

    3rd Floor, Navale IT park Phase 2,

    Pune Banglore Highway,

    Narhe, Pune, Maharashtra 411041, India.

    Email: [email protected]

    Phone No.: +91 20 6630 3320

    Website: www.maximizeMarketresearch.com

    Related Link :
    Global Hydraulic Cylinder Marke industry, market trends, size,growth ,Revenue and outlook 2027. The research report provides deep insights into the global market revenue, parent market trends, macro-economic indicators, and governing factors, along with market attractiveness per market segment. The report provides an overview of the growth rate of Hydraulic Cylinder Market during the forecast period. Most importantly, the report further identifies the qualitative impact of various market factors on market segments and geographies. The research segments the Hydraulic Cylinder Market on the basis of product type, application, technology, and region. To offer more clarity regarding the Hydraulic Cylinder Market Industry, the report takes a closer look at the current status of various factors including but not limited to supply chain management, niche markets, distribution channel, trade, supply, and demand and production capability across different countries. Hydraulic Cylinder Market Overview: This study looks at the market growth drivers and roadblocks for the manufacturer, as well as an assessment of the market's firm strategies, procedures, and financially sound and grow plan. Individual customer requirements can be satisfied through customization and a deep understanding of market opportunities. TheHydraulic Cylinder Market provides a comprehensive overview of the market's competitive landscape and key players. This report can assist with structural planning in light of current industry conditions. Expected Growth Value Of Hydraulic Cylinder Market : Hydraulic Cylinder Market size was valued at US$ 13.40 Bn. in 2020 and the total revenue is expected to grow at a CAGR of 3.5% through 2021 to 2027, reaching nearly US$ 17.05 Bn. Hydraulic Cylinder Market Market Scope: As per the forecast period 2021-2027, the Hydraulic Cylinder market is expected to grow at a steady rate of between 2021 and 2027. This study covers the Hydraulic Cylinder market and provides a value-based analysis and estimate. This study and analysis of market drivers, restraints, and opportunities affecting the growth of the Hydraulic Cylinder Market is included in this report. The global market has been segmented into four categories: type, source, end-user, and geography (country-wise). The scope of the research is a strategic analysis of the Hydraulic Cylinder market in terms of individual growth trends, future prospects, and the contributions of important sub-market stakeholders. Hydraulic Cylinder market analyses and forecasts for five key regions: North America, Europe, Asia Pacific, the Middle East and Africa (MEA), and Latin America, as well as country-by-country segmentation. Major industry participants' profiles, as well as their strategic orientations, market positioning, and core competence analysis, are offered. The top players in the Hydraulic Cylinder Market are also profiled, with details on their recent competitive advancements, investments, strategic growth, and competitive landscape. Get Sample Copy (Including FULL TOC, Graphs and Tables) Of This Report :https://www.maximizemarketresearch.com/request-sample/3211 Precision Farming Market Drivers: The construction industry's difficult and massive infrastructure development projects are growing increasingly complex. Despite the fact that the COVID-19 pandemic has had a negative impact on the construction industry, it is expected to grow significantly following the pandemic, due to improved infrastructure spending in APAC and rebounding European infrastructure investment. Backhoes, excavators, trenchers, road construction planers, and dumpers are among the construction equipment (fitted with hydraulic cylinders) that are projected to see increased demand as a result of new infrastructure development plans and projects. As a result, the market for hydraulic cylinders is expected to grow. Hydraulic cylinders use hydraulic fluids, primarily oil, to work. Oil leakage in hydraulic cylinders is caused by a wide variety of reasons including improper fittings and connections, as well as external conditions such as vibrations, shocks, and temperature fluctuations. The problem of leakage exists mostly in industries such as mining and construction, which involve substantial earthworks and the deployment of huge fixed and mobile units in environmentally sensitive locations. This leak is not only costly, but it is also dangerous to the environment and employees. Furthermore, unforeseen leakage causes delays in the aircraft sector, resulting in exorbitant costs, especially when these incidents occur on a regular basis. Precision Farming Market Segmentation: Based on the Bore Size, the market is segmented into <50 mm, 50–150 mm, and >150 mm. 50–150 mm bore size segment is expected to grow rapidly at a CAGR of xx% during the forecast period 2021-2027. This is due to the rapid development of storage and material handling infrastructure, as well as the upgrading of agricultural equipment and the growth of building activities. Based on the Industry, the market is segmented into Agriculture, Construction, Material Handling, Mining, Aerospace and Defense, Automotive, Oil and Gas, and Marine. Agriculture segment is expected to grow rapidly at a CAGR of xx% during the forecast period 2021-2027. Agriculture-based countries in APAC, such as India, Nepal, and Myanmar, are seeing increased demand for agricultural equipment as they ramp up production of wheat, rice, cotton, and sugarcane to meet export demands from the United States, Hong Kong, Germany, and Vietnam, among others. This has resulted in higher expenditures in precision agriculture tools and equipment, which is expected to fuel demand for hydraulic cylinders in the agriculture industry. Some prominent players in the Hydraulic Cylinder Market: • KYB Corporation • Parker-Hannifin Corporation • SMC Corporation • Jiangsu Hengli Hydraulic • Wipro Enterprises • HYDAC • Burnside Autocyl • JARP Industries • Kappa Engineering • Ligon Hydraulic Cylinder Group • Marrel Click Here For Instant Inquiry :https://www.maximizemarketresearch.com/inquiry-before-buying/3211 Regional Insights on Hydraulic Cylinder Market : The several sections on regional segmentation provide information on the regional characteristics of the Hydraulic Cylinder Market. This chapter discusses the regulatory environment that will have an impact on the market. It highlights the market’s political landscape & anticipates its impact on the worldwide Hydraulic Cylinder Market industry. Global brands’ presence and availability, as well as the problems they face from fierce competition from local & domestic brands, the influence of domestic tariffs, and trade channels, are all considered. The Hydraulic Cylinder Market report examines the five areas & their distribution by country: North America – (U.S., Canada, and Mexico) Europe – (U.K., Germany, France, Spain, Italy, Sweden, CIS Countries, and Rest of Europe) Asia Pacific – (China, India, Japan, South Korea, Australia, ASEAN, and Rest of APAC) Middle East & Africa – (South Africa, GCC Countries, Nigeria, Egypt, and Rest of ME&A) South America – (Brazil, Argentina, Colombia, and Rest of South America) COVID-19 Impact Analysis on Hydraulic Cylinder Market: The recovery phase of the COVID-19 outbreak has come to an end over the world. Maximize Industry Research has released the Hydraulic Cylinder Market Status, Trends, and COVID-19 Impact Report 2021, which gives a detailed look at the Hydraulic Cylinder market in light of the present economic situation. To Gain More Insights into the Market Analysis, Browse Summary of the Research Report :https://www.maximizemarketresearch.com/market-report/global-hydraulic-cylinder-market/3211/ The report provides insights on the following: Market Penetration: Offers complete information on the market offered by the key players Market Development: Provides in-depth information about emerging market trends and analyses the markets Competitive Assessment & Intelligence: Provides a comprehensive assessment of market shares, strategies, products, and manufacturing capabilities of the leading key players operating in the market Contact us: MAXIMIZE MARKET RESEARCH PVT. LTD. 3rd Floor, Navale IT park Phase 2, Pune Banglore Highway, Narhe, Pune, Maharashtra 411041, India. Email: [email protected] Phone No.: +91 20 6630 3320 Website: www.maximizeMarketresearch.com Related Link :
    WWW.MAXIMIZEMARKETRESEARCH.COM
    Request Sample
    for Request Sample fill the form
    0 Comments 0 Shares 527 Views
  • https://urbanscoop.news/immigration-and-the-sligo-murders/
    https://urbanscoop.news/immigration-and-the-sligo-murders/
    URBANSCOOP.NEWS
    Immigration And The Sligo Murders
    Immigration And The Sligo Murders. In the UK, when polls are taken, around 70% of people want less immigration. 
    0 Comments 0 Shares 155 Views
  • The events in Sligo; Ireland becomes a truly multicultural society!
    https://youtu.be/_2HqSB2Ccvs
    The events in Sligo; Ireland becomes a truly multicultural society! https://youtu.be/_2HqSB2Ccvs
    Like
    1
    0 Comments 0 Shares 297 Views
  • Everyone has a holiday or a month that gets celebrated. The black people has a month, they have a pride week, Juneteenth, the Spanish has the day Cinco de Mayo, the Irish has Saint Patrick's Day. The Chinese have lunar new year's. Even the Wiccans has a day. They have Sam Hain. The Japanese, they don't have a day. So, I want a day for them. Don't be a wiseass and say December 7. Cause I'll kick your ass.

    When white ppl say y'all don't have holidays, I call bullshit. What do you call Chirstmas, Easter, New Year's Day… You see, these are European Holidays. Christianity tried to stamp out Pagan religions that were more prevalent in Europe. Wiccans who belived in the Goddess, were more prevalent than Christianity. Xmas was put on Dec 25 or Winter solstice to stop people from celebrating Wicca. Easter was placed was put close to another solstice for the same reason.

    So, Christians, lmao your roots are that of fascist nature. Research your religion before you think that your religon is better than others. It isn't. I am Christian but understand where it comes from. I also understand that one needs the blind faith and values to have an orderly life. But will not attempt to recruit others into said religion.

    Christianity in its many flavors has also killed more people than Nazism, Communism, and Nuclear Weapons. It is ultimately satan. To use your own terminology. This is why I do not attend church, I do not preach scripture, but I do pray.
    Everyone has a holiday or a month that gets celebrated. The black people has a month, they have a pride week, Juneteenth, the Spanish has the day Cinco de Mayo, the Irish has Saint Patrick's Day. The Chinese have lunar new year's. Even the Wiccans has a day. They have Sam Hain. The Japanese, they don't have a day. So, I want a day for them. Don't be a wiseass and say December 7. Cause I'll kick your ass. When white ppl say y'all don't have holidays, I call bullshit. What do you call Chirstmas, Easter, New Year's Day… You see, these are European Holidays. Christianity tried to stamp out Pagan religions that were more prevalent in Europe. Wiccans who belived in the Goddess, were more prevalent than Christianity. Xmas was put on Dec 25 or Winter solstice to stop people from celebrating Wicca. Easter was placed was put close to another solstice for the same reason. So, Christians, lmao your roots are that of fascist nature. Research your religion before you think that your religon is better than others. It isn't. I am Christian but understand where it comes from. I also understand that one needs the blind faith and values to have an orderly life. But will not attempt to recruit others into said religion. Christianity in its many flavors has also killed more people than Nazism, Communism, and Nuclear Weapons. It is ultimately satan. To use your own terminology. This is why I do not attend church, I do not preach scripture, but I do pray.
    Like
    1
    0 Comments 0 Shares 620 Views
  • Matt Williams - A Highly Eccentric Black Hole Merger Detected for the First Time:

    https://www.universetoday.com/154281/a-highly-eccentric-black-hole-merger-detected-for-the-first-time/

    #LIGO #LASER #Virgo #GravitationalWave #GeneralRelativity #CCRG #ICERM #GW150521 #BlackHole #BlackHoleMerger #Merger #BlackHoleBinary #Supermassive #SMBH #NeutronStar #NeutronStarMerger #EccentricOrbit #HubbleConstant #Cosmology #Astronomy
    Matt Williams - A Highly Eccentric Black Hole Merger Detected for the First Time: https://www.universetoday.com/154281/a-highly-eccentric-black-hole-merger-detected-for-the-first-time/ #LIGO #LASER #Virgo #GravitationalWave #GeneralRelativity #CCRG #ICERM #GW150521 #BlackHole #BlackHoleMerger #Merger #BlackHoleBinary #Supermassive #SMBH #NeutronStar #NeutronStarMerger #EccentricOrbit #HubbleConstant #Cosmology #Astronomy
    WWW.UNIVERSETODAY.COM
    A Highly Eccentric Black Hole Merger Detected for the First Time
    Recent research into a gravitational wave event has revealed new insights into black hole mergers, cosmic expansion, and the growth of supermassive black holes.
    0 Comments 0 Shares 3366 Views
  • * * Ranchers sell cattle cheap while meat packing oligopoly reaps record profits

    https://mattstoller.substack.com/p/economists-to-cattle-ranchers-stop

    * * Ranchers sell cattle cheap while meat packing oligopoly reaps record profits https://mattstoller.substack.com/p/economists-to-cattle-ranchers-stop
    MATTSTOLLER.SUBSTACK.COM
    Economists to Cattle Ranchers: Stop Being So Emotional About the Monopolies Devouring Your Family Businesses
    Agricultural economists manipulated data to block Congress from acting on high beef prices and the destruction of independent cattle ranching. Why? Because they think monopolies are good.
    0 Comments 0 Shares 281 Views
  • https://pubmed.ncbi.nlm.nih.gov/26814441/

    Nanoscale
    . 2016 Feb 14;8(6):3785-95. doi: 10.1039/c5nr09208f. Epub 2016 Jan 27.
    Functionalized graphene oxide serves as a novel vaccine nano-adjuvant for robust stimulation of cellular immunity
    Ligeng Xu 1, Jian Xiang, Ye Liu, Jun Xu, Yinchan Luo, Liangzhu Feng, Zhuang Liu, Rui Peng
    Affiliations collapse
    Affiliation
    1Institute of Functional Nano & Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon-based Functional Materials & Devices, Soochow University, Suzhou, 215123, P.R. China. [email protected] [email protected].
    PMID: 26814441 DOI: 10.1039/c5nr09208f
    Free article
    Abstract
    Benefiting from their unique physicochemical properties, graphene derivatives have attracted great attention in biomedicine. In this study, we carefully engineered graphene oxide (GO) as a vaccine adjuvant for immunotherapy using urease B (Ure B) as the model antigen. Ure B is a specific antigen for Helicobacter pylori, which is a class I carcinogen for gastric cancer. Polyethylene glycol (PEG) and various types of polyethylenimine (PEI) were used as coating polymers. Compared with single-polymer modified GOs (GO-PEG and GO-PEI), certain dual-polymer modified GOs (GO-PEG-PEI) can act as a positive modulator to promote the maturation of dendritic cells (DCs) and enhance their cytokine secretion through the activation of multiple toll-like receptor (TLR) pathways while showing low toxicity. Moreover, this GO-PEG-PEI can serve as an antigen carrier to effectively shuttle antigens into DCs. These two advantages enable GO-PEG-PEI to serve as a novel vaccine adjuvant. In the subsequent in vivo experiments, compared with free Ure B and clinically used aluminum-adjuvant-based vaccine (Alum-Ure B), GO-PEG-PEI-Ure B induces stronger cellular immunity via intradermal administration, suggesting promising applications in cancer immunotherapy. Our work not only presents a novel, highly effective GO-based vaccine nano-adjuvant, but also highlights the critical roles of surface chemistry for the rational design of nano-adjuvants.

    Similar articles
    Alum-functionalized graphene oxide nanocomplexes for effective anticancer vaccination.
    Wang X, Cao F, Yan M, Liu Y, Zhu X, Sun H, Ma G.
    Acta Biomater. 2019 Jan 1;83:390-399. doi: 10.1016/j.actbio.2018.11.023. Epub 2018 Nov 15.
    PMID: 30448435
    Synthesis of polymer-functionalized nanoscale graphene oxide with different surface charge and its cellular uptake, biosafety and immune responses in Raw264.7 macrophages.
    Wang B, Su X, Liang J, Yang L, Hu Q, Shan X, Wan J, Hu Z.
    Mater Sci Eng C Mater Biol Appl. 2018 Sep 1;90:514-522. doi: 10.1016/j.msec.2018.04.096. Epub 2018 May 1.
    PMID: 29853120
    Immunostimulatory oligonucleotides-loaded cationic graphene oxide with photothermally enhanced immunogenicity for photothermal/immune cancer therapy.
    Tao Y, Ju E, Ren J, Qu X.
    Biomaterials. 2014 Dec;35(37):9963-9971. doi: 10.1016/j.biomaterials.2014.08.036. Epub 2014 Sep 15.
    PMID: 25224368
    Recent progress of graphene oxide as a potential vaccine carrier and adjuvant.
    Cao W, He L, Cao W, Huang X, Jia K, Dai J.
    Acta Biomater. 2020 Aug;112:14-28. doi: 10.1016/j.actbio.2020.06.009. Epub 2020 Jun 10.
    PMID: 32531395 Review.
    Particulate formulations for the delivery of poly(I:C) as vaccine adjuvant.
    Hafner AM, Corthésy B, Merkle HP.
    Adv Drug Deliv Rev. 2013 Oct;65(10):1386-99. doi: 10.1016/j.addr.2013.05.013. Epub 2013 Jun 7.
    PMID: 23751781 Review.
    See all similar articles
    Cited by 7 articles
    Intranasal vaccination with influenza HA/GO-PEI nanoparticles provides immune protection against homo- and heterologous strains.
    Dong C, Wang Y, Gonzalez GX, Ma Y, Song Y, Wang S, Kang SM, Compans RW, Wang BZ.
    Proc Natl Acad Sci U S A. 2021 May 11;118(19):e2024998118. doi: 10.1073/pnas.2024998118.
    PMID: 33941704 Free PMC article.
    SPIO Enhance the Cross-Presentation and Migration of DCs and Anionic SPIO Influence the Nanoadjuvant Effects Related to Interleukin-1β.
    Liu H, Dong H, Zhou N, Dong S, Chen L, Zhu Y, Hu HM, Mou Y.
    Nanoscale Res Lett. 2018 Dec 20;13(1):409. doi: 10.1186/s11671-018-2802-0.
    PMID: 30570682 Free PMC article.
    Nanoparticle Vaccines Adopting Virus-like Features for Enhanced Immune Potentiation.
    Chattopadhyay S, Chen JY, Chen HW, Hu CJ.
    Nanotheranostics. 2017 Jun 9;1(3):244-260. doi: 10.7150/ntno.19796. eCollection 2017.
    PMID: 29071191 Free PMC article. Review.
    Single-cell mass cytometry and transcriptome profiling reveal the impact of graphene on human immune cells.
    Orecchioni M, Bedognetti D, Newman L, Fuoco C, Spada F, Hendrickx W, Marincola FM, Sgarrella F, Rodrigues AF, Ménard-Moyon C, Cesareni G, Kostarelos K, Bianco A, Delogu LG.
    Nat Commun. 2017 Oct 24;8(1):1109. doi: 10.1038/s41467-017-01015-3.
    PMID: 29061960 Free PMC article.
    Graphene and the Immune System: A Romance of Many Dimensions.
    Mukherjee SP, Bottini M, Fadeel B.
    Front Immunol. 2017 Jun 13;8:673. doi: 10.3389/fimmu.2017.00673. eCollection 2017.
    https://pubmed.ncbi.nlm.nih.gov/26814441/ Nanoscale . 2016 Feb 14;8(6):3785-95. doi: 10.1039/c5nr09208f. Epub 2016 Jan 27. Functionalized graphene oxide serves as a novel vaccine nano-adjuvant for robust stimulation of cellular immunity Ligeng Xu 1, Jian Xiang, Ye Liu, Jun Xu, Yinchan Luo, Liangzhu Feng, Zhuang Liu, Rui Peng Affiliations collapse Affiliation 1Institute of Functional Nano & Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon-based Functional Materials & Devices, Soochow University, Suzhou, 215123, P.R. China. [email protected] [email protected]. PMID: 26814441 DOI: 10.1039/c5nr09208f Free article Abstract Benefiting from their unique physicochemical properties, graphene derivatives have attracted great attention in biomedicine. In this study, we carefully engineered graphene oxide (GO) as a vaccine adjuvant for immunotherapy using urease B (Ure B) as the model antigen. Ure B is a specific antigen for Helicobacter pylori, which is a class I carcinogen for gastric cancer. Polyethylene glycol (PEG) and various types of polyethylenimine (PEI) were used as coating polymers. Compared with single-polymer modified GOs (GO-PEG and GO-PEI), certain dual-polymer modified GOs (GO-PEG-PEI) can act as a positive modulator to promote the maturation of dendritic cells (DCs) and enhance their cytokine secretion through the activation of multiple toll-like receptor (TLR) pathways while showing low toxicity. Moreover, this GO-PEG-PEI can serve as an antigen carrier to effectively shuttle antigens into DCs. These two advantages enable GO-PEG-PEI to serve as a novel vaccine adjuvant. In the subsequent in vivo experiments, compared with free Ure B and clinically used aluminum-adjuvant-based vaccine (Alum-Ure B), GO-PEG-PEI-Ure B induces stronger cellular immunity via intradermal administration, suggesting promising applications in cancer immunotherapy. Our work not only presents a novel, highly effective GO-based vaccine nano-adjuvant, but also highlights the critical roles of surface chemistry for the rational design of nano-adjuvants. Similar articles Alum-functionalized graphene oxide nanocomplexes for effective anticancer vaccination. Wang X, Cao F, Yan M, Liu Y, Zhu X, Sun H, Ma G. Acta Biomater. 2019 Jan 1;83:390-399. doi: 10.1016/j.actbio.2018.11.023. Epub 2018 Nov 15. PMID: 30448435 Synthesis of polymer-functionalized nanoscale graphene oxide with different surface charge and its cellular uptake, biosafety and immune responses in Raw264.7 macrophages. Wang B, Su X, Liang J, Yang L, Hu Q, Shan X, Wan J, Hu Z. Mater Sci Eng C Mater Biol Appl. 2018 Sep 1;90:514-522. doi: 10.1016/j.msec.2018.04.096. Epub 2018 May 1. PMID: 29853120 Immunostimulatory oligonucleotides-loaded cationic graphene oxide with photothermally enhanced immunogenicity for photothermal/immune cancer therapy. Tao Y, Ju E, Ren J, Qu X. Biomaterials. 2014 Dec;35(37):9963-9971. doi: 10.1016/j.biomaterials.2014.08.036. Epub 2014 Sep 15. PMID: 25224368 Recent progress of graphene oxide as a potential vaccine carrier and adjuvant. Cao W, He L, Cao W, Huang X, Jia K, Dai J. Acta Biomater. 2020 Aug;112:14-28. doi: 10.1016/j.actbio.2020.06.009. Epub 2020 Jun 10. PMID: 32531395 Review. Particulate formulations for the delivery of poly(I:C) as vaccine adjuvant. Hafner AM, Corthésy B, Merkle HP. Adv Drug Deliv Rev. 2013 Oct;65(10):1386-99. doi: 10.1016/j.addr.2013.05.013. Epub 2013 Jun 7. PMID: 23751781 Review. See all similar articles Cited by 7 articles Intranasal vaccination with influenza HA/GO-PEI nanoparticles provides immune protection against homo- and heterologous strains. Dong C, Wang Y, Gonzalez GX, Ma Y, Song Y, Wang S, Kang SM, Compans RW, Wang BZ. Proc Natl Acad Sci U S A. 2021 May 11;118(19):e2024998118. doi: 10.1073/pnas.2024998118. PMID: 33941704 Free PMC article. SPIO Enhance the Cross-Presentation and Migration of DCs and Anionic SPIO Influence the Nanoadjuvant Effects Related to Interleukin-1β. Liu H, Dong H, Zhou N, Dong S, Chen L, Zhu Y, Hu HM, Mou Y. Nanoscale Res Lett. 2018 Dec 20;13(1):409. doi: 10.1186/s11671-018-2802-0. PMID: 30570682 Free PMC article. Nanoparticle Vaccines Adopting Virus-like Features for Enhanced Immune Potentiation. Chattopadhyay S, Chen JY, Chen HW, Hu CJ. Nanotheranostics. 2017 Jun 9;1(3):244-260. doi: 10.7150/ntno.19796. eCollection 2017. PMID: 29071191 Free PMC article. Review. Single-cell mass cytometry and transcriptome profiling reveal the impact of graphene on human immune cells. Orecchioni M, Bedognetti D, Newman L, Fuoco C, Spada F, Hendrickx W, Marincola FM, Sgarrella F, Rodrigues AF, Ménard-Moyon C, Cesareni G, Kostarelos K, Bianco A, Delogu LG. Nat Commun. 2017 Oct 24;8(1):1109. doi: 10.1038/s41467-017-01015-3. PMID: 29061960 Free PMC article. Graphene and the Immune System: A Romance of Many Dimensions. Mukherjee SP, Bottini M, Fadeel B. Front Immunol. 2017 Jun 13;8:673. doi: 10.3389/fimmu.2017.00673. eCollection 2017.
    PUBMED.NCBI.NLM.NIH.GOV
    Functionalized graphene oxide serves as a novel vaccine nano-adjuvant for robust stimulation of cellular immunity - PubMed
    Benefiting from their unique physicochemical properties, graphene derivatives have attracted great attention in biomedicine. In this study, we carefully engineered graphene oxide (GO) as a vaccine adjuvant for immunotherapy using urease B (Ure B) as the model antigen. Ure B is a specific antigen for …
    Like
    1
    0 Comments 0 Shares 769 Views
More Results
Sponsored

We are now 100% funded for April. I am matching donations dollar for dollar this month. Thanks to everyone who helped out. 🥰

Xephula monthly operating expenses for 2024 - Server: $143/month - Backup Software: $6/month - Object Storage: $6/month - SMTP Service: $10/month - Stripe Processing Fees: ~$10/month - Total: $175/month

Xephula Funding Meter

Please Donate Here