https://www.nature.com/articles/s41419-021-04058-z Starting from day +1 after receiving the vaccine ChAdOx1 nCOV-19 (Oxford-Astrazeneca), a 48-year-old Caucasian woman reported progressive headache, back pain, moderate right lower limb pain, and disseminated ecchymosis that required hospitalization on day +18 for 7 days (S. Eugenio Hospital, Rome). On day +22, the patient required a transfer to the neurology intensive care unit to improve her management, as a significative intensification of headache, confusion, nausea, and vomiting emerged.