Ivermectin is a specific inhibitor of importin...

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2021-09-06 23:34:24 -

So they say Ivermectin is an anti-parasite drug OK but then why was it I'd in 2012 is a potent antiviral?
Works on HIV? is Ivermectin in HIV cocktails now?

From the abstract:
Importantly, we establish for the first time that ivermectin has potent antiviral activity towards both HIV-1 and dengue virus, both of which are strongly reliant on importin α/β nuclear import, with respect to the HIV-1 integrase and NS5 (non-structural protein 5) polymerase proteins respectively. Ivermectin would appear to be an invaluable tool for the study of protein nuclear import, as well as the basis for future development of antiviral agents.

Source:
https://pubmed.ncbi.nlm.nih.gov/22417684/

So they say Ivermectin is an anti-parasite drug OK but then why was it I'd in 2012 is a potent antiviral? Works on HIV? is Ivermectin in HIV cocktails now? From the abstract: Importantly, we establish for the first time that ivermectin has potent antiviral activity towards both HIV-1 and dengue virus, both of which are strongly reliant on importin α/β nuclear import, with respect to the HIV-1 integrase and NS5 (non-structural protein 5) polymerase proteins respectively. Ivermectin would appear to be an invaluable tool for the study of protein nuclear import, as well as the basis for future development of antiviral agents. Source: https://pubmed.ncbi.nlm.nih.gov/22417684/

PUBMED.NCBI.NLM.NIH.GOV

Ivermectin is a specific inhibitor of importin α/β-mediated nuclear import able to inhibit replication of HIV-1 and dengue virus - PubMed

The movement of proteins between the cytoplasm and nucleus mediated by the importin superfamily of proteins is essential to many cellular processes, including differentiation and development, and is critical to disease states such as viral disease and oncogenesis. We recently developed a high-throug …

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